Fig. 2.

The Effects of Sertraline Treatment on Body Weight and Composition. The data were analyzed using 2 (Pretreatment, Treatment) × 2 (Placebo, Sertraline) × 2 (Nondepressed, Depressed) analyses of variance (ANOVAs). In order to adjust for Pretreatment differences the data were also analyzed by 2 (Placebo, Sertraline) × 2 (Nondepressed, Depressed) analyses of covariance (ANCOVAs) adjusted for Pretreatment values. (A) Body weight increased during the treatment phase in placebo-treated, but not sertraline-treated monkeys (ANOVA treatment × phase interaction F[1,38] = 10.2, p = 0.003; ANCOVA treatment effect F[1,37] = 11.9, p = 0.001). (B) Sertraline had no effect on body mass index (ANOVA treatment × phase interaction F[1,38] = 0.54, p = 0.47; ANCOVA treatment effect F[1,37] = 0.45, p = 0.51). C. Whole body fat mass increased during the treatment phase in placebo-treated, but not sertraline-treated monkeys (ANOVA treatment × phase interaction) F[1,38] = 6.22, p = 0.017; ANCOVA treatment effect F[1,37] = 5.56, p = 0.02 Placebo treatment: blue; Sertraline treatment: red. Nondepressed: Solid lines or bars; Depressed: dotted lines or hatched bars (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)