Table 4.

Adjusted associations between traumatic brain injury with loss of consciousness at any age and neuropathological findings from analysis of pooled data from all three studies^*

Outcome	TBI with LOC < 1 hr (n=176)		TBI with LOC ≥1 hr (n=37)
	RR (95% CI)	P value	RR (95% CI)	P value
Braak Stage 5 or 6	1.02 (0.79, 1.33)	0.88	0.98 (0.58, 1.65)	0.93
CERAD intermediate or   frequent	1.01 (0.89, 1.15)	0.88	1.00 (0.79, 1.27)	0.98
Amyloid angiopathy	1.08 (0.99, 1.19)	0.09	1.09 (0.93. 1.27)	0.28
Cystic infarcts	0.90 (0.73, 1.12)	0.35	1.17 (0.84, 1.62)	0.34
Hippocampal sclerosis	0.91 (0.51, 1.61)	0.75	1.34 (0.62, 2.89)	0.45
Cerebral Microinfarcts
Any	0.94 (0.76, 1.15)	0.54	1.18 (0.85, 1.66)	0.32
Any cortical	0.90 (0.68, 1.19)	0.47	1.58 (1.06, 2.35)	0.026
Any deep	1.02 (0.78, 1.33)	0.90	1.30 (0.83, 2.05)	0.25
Lewy bodies
Any	1.00 (0.73, 1.37)	0.99	1.44 (0.87, 2.39)	0.16
Substantia Nigra / Locus     Ceruleus	1.04 (0.74, 1.45)	0.84	1.48 (0.86, 2.55)	0.16
Frontal or temporal cortex	1.59 (1.06, 2.39)	0.025	1.75 (0.82, 3.77)	0.15
Amygdala / limbic	1.22 (0.88, 1.69)	0.24	1.16 (0.59, 2.27)	0.67

^*See footnotes to Table 3. Across the three studies there were 1,439 people with no reported TBI with LOC. These models adjusted for age at death, sex, years of education, and indicator terms for ROS, MAP, and three different enrollment groups for ACT