Table 2.

Total of 1 × 10⁷ NOD.Rag1^null.AI4 splenocytes fail to transfer T1D into unmanipulated genetically modified stocks of NOD mice that lack T cells or B cells, but they efficiently induce disease in NOD.Rag1^null mice lacking both cell types

Recipient*	Fraction diabetic	Percent diabetic	χ2 P value†
NOD.IFN-γnull	5/5	100	—
NOD	0/5	0	<0.01
NOD.IgHnull	0/5	0	<0.01
NOD.TCRαnull	0/5	0	<0.01
NOD.CD8null	0/6	0	<0.001
NOD.Rag1null	7/7	100	NS

*Recipients were monitored for diabetes development for 10 weeks after adoptive transfer of AI4 splenocytes.

†P values from χ² analyses comparing the frequency of AI4 T cell–induced T1D between NOD.IFN-γ^null mice and NOD, NOD.IgH^null, NOD.TCRα^null, NOD.CD8^null, and NOD.Rag1^null stocks.