Table 3.
Multi-variable adjusted association between birthweight and placental vitamin D metabolism-related genotypes
| Birthweight in grams a |
||||
|---|---|---|---|---|
| Locus (Index SNP, Effect allele/Other allele) | All infants | Female Infants | Male Infants | Low birthweight b (< 2500 grams) |
| N=506 | N=252 | N=254 | N=24 (4.7%) | |
| CUBN (rs1801231,C/T) | −13.1 (−96.7, 70.5) | 62.3 (−54.1, 178.7) | −67.6 (−188.2, 53.0) | 1.26 (0.39 - 4.05) |
| CUBN (rs1801224,C/A) | 0.65 (−70.1, 71.4) | −33.5 (−131.3, 64.2) | 27.3 (−74.1, 128.6) | 1.04 (0.33 - 3.28) |
| CUBN (rs1801222,T/C) | −18.6 (−85.9, 48.8) | −31.3 (−121.3, 58.8) | −31.3 (−132.7, 69.6) | 2.06 (0.76 - 5.57) |
| LRP2 (rs4667591,T/G) | 7.6 (−65.2, 80.3) | 124.6** (20.1, 229.0) | −81.6 (−183.7, 20.5) | 1.04 (0.34 - 3.22) |
| LRP2 (rs2229263,G/A) | 17.2 (−47.2, 81.7) | 22.4 (−65.0, 109.7) | −2.7 (−100.8, 95.3) | 1.16 (0.47 - 2.88) |
| VDR (rs2228570,T/G) | −4.8 (−69.1, 59.6) | −35.1 (−123.4, 53.2) | 50.7 (−42.9, 144.3) | 1.92 (0.71 - 5.19) |
| GC (rs2282679,C/A) | 78.6** (11.1, 146.2) | 57.7 (−36.1, 151.4) | 94.6* (−3.3, 192.4) | 0.53 (0.18 – 1.62) |
| CYP2R1 (rs10741657,A/G) | −3.8 (−66.4, 58.8) | −2.6 (−88.4, 83.3) | −16.7 (−107.9, 74.5) | 1.89 (0.75 - 4.75) |
| Genetic risk Score (GRS) | 1.36 (0.41, 2.30) | 0.29 (−0.22, 0.80) | 0.41 (−0.09, 0.90) | 0.98 (0.99 - 1.01) |
a
β (95% CI), adjusted for sex, race and gestational age (only race and gestational age included for sex-specific models)
b
OR (95% CI), adjusted for sex, race and gestational age
**
Statistically significant estimates
Note: P-values for sex interaction: rs4667591 (0.001), rs1801231 (0.03)