Table I.

Laboratory testing to investigate autoimmune and prothrombotic states in patients with chronic non-healing wounds.

Test	Disease detected
Anti-nuclear antibody	Systemic Lupus Erythematosus and other autoimmune diseases
Anti-Smith antibody	Systemic Lupus Erythematosus
Anti-dsDNA antibody	Systemic Lupus Erythematosus
Complement C3 Complement C4	Systemic Lupus Erythematosus (low in active disease)
Anti-Centromere antibody	Scleroderma
Anti-Scl70 antibody	Scleroderma
Anti-ribonuclear protein (RNP)	Mixed connective tissue disease
SSA and SSB antibodies	Sjogrens Syndrome
Rheumatoid Factor	Rheumatoid Arthritis
Anti-Cyclic Citrullinated Peptide	Rheumatoid Arthritis
Anti-neutrophil cytoplasmic antibodies	Granulomatosis with polyangiitis, Microscopic Polyangiitis, Eosinophilic granulomatosis with polyangiitis, Cocaine and Levamisole associated vasculitis
Anti-β2-glycoprotein I antibodies	Antiphospholipid syndrome
Anti-cardiolipin antibodies	Antiphospholipid syndrome
Lupus Anticoagulant	Antiphospholipid syndrome
Prothrombin gene mutation	Genetic prothrombotic state
Factor-V Leiden mutation	Genetic prothrombotic state
Plasminogen Activator Inhibitor	Genetic prothrombotic state
MTHFR mutation	Genetic prothrombotic state
Quantiferon gold	Tuberculosis exposure
HIV test	HIV
Hepatitis B and C	Hepatitis B and C