Table 3. Risk factors associated with TB incidence according to the presence of BCG scar in household contacts of smear-positive TB patients in Colombia.
| Factor | Without BCG scar | With BCG scar | ||
|---|---|---|---|---|
| (n = 354) | (n = 1313) | |||
| Adjusted HR¶ | (95% CI) | Adjusted HR¶ | (95% CI) | |
| PPD-induced mitochondrial damage | ||||
| No | 1 | 1 | ||
| Yes | 1,65 | (0,2–13,2) | 0,19* | (0,1–0,5) |
| Age, years | ||||
| ≤ 4 | 2,87 | (0,6–14,3) | 1,22 | (0,3–4,5) |
| 5–14 | ND | ND | 0,48 | (0,2–1,6) |
| 15 or more | 1 | 1 | ||
| Comorbidity | ||||
| No | 1 | 1 | ||
| Yes | 1,17 | (0,2–6,1) | 3,06* | (1,1–8,2) |
| Nutritional status | ||||
| Normal | 1 | 1 | ||
| Overweight | 0,97 | (0,2–4,5) | 0,32 | (0,1–1,5) |
| Underweight | 1,46 | (0,2–9,1) | 1,17 | (0,4–3,9) |
| Proximity to the index case | ||||
| HHC slept in other household | 1 | 1 | ||
| HHC slept in same household | 0,79 | (0,1–7,2) | 2,81** | (0,9–8,8) |
| HHC slept in same room | 1,1 | (0,2–5,8) | 1,6 | (0,5–5,3) |
| Persons per room | ||||
| Less than 3 | 1 | 1 | ||
| 3 or more | 2,61 | (0,7–10,4) | 2,03 | (0,8–5,4) |
ND = No data. HHC: Household contacts. BCG: Bacillus Calmette-Guérin
¶ Hazard Ratio adjusted by age, comorbidity, nutritional status, proximity of exposure to case and overcrowding
* p <0.05
** p <0.10