Fig 1. Effect of oral administration of essential oil from peel (EOP) and seed (EOS) in inhibition of leukocyte migration at both doses tested in pleurisy test.

Mice were treated one hour before an intrapleural injection of carrageenan, with EOS and EOP (100 or 300 mg/kg), dexamethasone (dexa, 1 mg/kg, s.c.), or saline solution (Vehicle). Naive group, also treated with saline p.o., received an intrapleural injection of sterile saline. The bars express the mean ± SEM of 5 animals. * p<0.001 when compared to control group. Differences between groups were analyzed by analysis of variance (one-way ANOVA) followed by the Newman-Keuls test.