Fig 4. Effect of oral administration of essential oil from peel (EOP) and seed (EOS) from C. adamantium fruits in formalin-induced cold sensitivity and oedema induced by formalin.

(A) Effect of essential oils of C. Adamantium fruit on cold sensitivity after treatment with EOP and EOS. (B) Oedema induced by formalin. Each bar represents the mean ± SEM of 5 animals. *P <0.001 when compared to the control group. Differences among groups were analyzed by analysis of variance (one-way ANOVA) followed by the Newman-Keuls test.