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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: J Mol Cell Cardiol. 2016 Oct 13;100:109–117. doi: 10.1016/j.yjmcc.2016.10.005

Fig. 8.

Fig. 8

MMP-9 global deletion changes the baseline ECM profile in mice. Extracellular matrix protein 1 (ECM1), fibronectin, and periostin were key ECM protein differences identified between wild type and MMP-9 null plasma at baseline. Important feature analysis visualized with a volcano plot showed the ECM1 and fibronectin were lower and periostin was higher in MMP-9 null plasma from day 0 (no MI) mice. The y threshold was set at 1.3 fold change (red line intersecting the y-axis). The x threshold was set at −0.5 and +0.5 (black line intersecting the x-axis). The pink circles represent features outside the threshold points. Both fold change and p value are log transformed. Proteins in red (Ecm1 and fibronectin) were significantly decreased in MMP-9 null compared to wild type mice (p < 0.05). Proteins in black (periostin and sulfhydryl oxidase 1a) were significantly increased in MMP-9 null compared to wild type mice (p < 0.05). n = 10/group.