Table 4.
MMP-9 null | MMP-9 inhibitor | |
---|---|---|
Infarct area | ↔ | ↔ |
Survival rate | ↑ | ↔ |
LV remodeling | Improved | Worsened |
Rupture rate | ↓ | ↔ |
Collagen deposition | ↓ | ↓ |
Inflammatory gene expression | ↓ | ↑ |
Neutrophils at D1 post-MI | ↔ | ↑ |
Neutrophils at D7 post-MI | ↓ | ↔ |
Macrophage infiltration | ↓ | ↑ |
CD36 levels | ↑ | ↓ |
Cell apoptosis | ↑ | ↓ |
Post-MI MMP levels | ↑ MMP-2, -13, TIMP-1 | ↑ MMP-8, -12, -14 |
Pre-MI MMP levels | ↑ MMP-3, -13 | ↔ |