Table 4.
Comparative analysis of events pre- and post-MI between MMP-9 null and wild type MMP-9i treated group [6–9,11,18,29,34,43].
| MMP-9 null | MMP-9 inhibitor | |
|---|---|---|
| Infarct area | ↔ | ↔ |
| Survival rate | ↑ | ↔ |
| LV remodeling | Improved | Worsened |
| Rupture rate | ↓ | ↔ |
| Collagen deposition | ↓ | ↓ |
| Inflammatory gene expression | ↓ | ↑ |
| Neutrophils at D1 post-MI | ↔ | ↑ |
| Neutrophils at D7 post-MI | ↓ | ↔ |
| Macrophage infiltration | ↓ | ↑ |
| CD36 levels | ↑ | ↓ |
| Cell apoptosis | ↑ | ↓ |
| Post-MI MMP levels | ↑ MMP-2, -13, TIMP-1 | ↑ MMP-8, -12, -14 |
| Pre-MI MMP levels | ↑ MMP-3, -13 | ↔ |