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. Author manuscript; available in PMC: 2017 Feb 21.
Published in final edited form as: Drug Metab Pharmacokinet. 2016 Apr 30;31(5):385–388. doi: 10.1016/j.dmpk.2016.04.005

Fig. 1.

Fig. 1

Mean plasma concentration–time profiles of metformin in male wild-type (Oct3+/+) and Oct3-knockout (Oct3−/−) mice after intravenous administration. Metformin (8 mg/kg containing 0.1 mCi/kg [14C] was intravenously administered by retro-orbital injection in male Oct3+/+ (open circles) and Oct3−/− mice (filled circles). Data are shown as the mean ± SEM (n = six to nine mice at each time point). A total of 26 Oct3+/+ and 26 Oct3−/− male mice were used for the pharmacokinetic studies.