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. 2017 Jan;102:94–107. doi: 10.1016/j.yjmcc.2016.10.010

Fig. 4.

Fig. 4

Thymosin β4 knockout hearts show reduced ventricular volumes and regional variability in wall motion. Representative two-chamber long axis (2-ch; A, B, E, F) and mid ventricular short axis (SA; C, D, G, H) images at end diastole (ED) and end systole (ES) for +/Y (A–D) and −/Y (E–H) mice. Images reveal small ED and ES volumes in −/Y mice. Bulls eye plots reveal a high local variability in fractional wall thickening (fWT) in −/Y LV myocardium (representative example in J, compared with +/Y, I). Segment-wise comparison of variances (% standard deviation (%SD) for +/Y (K) and −/Y (L) LV (Table A3; n = 8 +/Y; n = 9 −/Y), revealed greater variability in fWT in anterior (p < 0.05) and inferior segments of –Y LV (L, compared with K) while septal and lateral segments displayed reduced variability (Table A3).