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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Bioorg Med Chem. 2016 Nov 10;25(3):813–824. doi: 10.1016/j.bmc.2016.11.013

Table 1.

Activity of furoic acid species against RpMetAP1

graphic file with name nihms843186t1.jpg
Compound X R1 R2 R3 R4 IC50 (µM) Hill Slope
(1) S H H H H 74 ± 7 1.2 ± 0.2
(2) O H NO2 H H 77 ± 4 1.0 ± 0.1
(3) O H CF3 H H 46 ± 2 1.0 ± 0.1
(4) O H H H H 37 ± 3 1.0 ± 0.1
(5) O H H Me H 57 ± 2 1.0 ± 0.1
(6) O CF3 H H H 0.5 ± 0.1 2.1 ± 0.1
(7) O H H Br H 60 ± 5 1.0 ± 0.1
(8) O Me H H H 0.9 ± 0.1 1.3 ± 0.1
(9) O H Me H H 26 ± 1 1.0 ± 0.1
(10) O Cl H H H 0.6 ± 0.1 1.2 ± 0.1
(11) O Cl H H Cl 0.6 ± 0.1 0.6 ± 0.1