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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Bioorg Med Chem. 2016 Nov 10;25(3):813–824. doi: 10.1016/j.bmc.2016.11.013

Table 2.

Activity of triazole species against RpMetAP1

graphic file with name nihms843186t2.jpg
Compound R1 R2 IC50 (µM) Hill Slope
(12) H H 6.6 ± 1.0 1.1 ± 0.2
(13) H Me 23 ± 3 0.9 ± 0.1
(14) H F 28 ± 6 1.0 ± 0.2
(15) Cl H 15 ± 2 1.2 ± 0.1
(16) H Cl 30 ± 2 1.6 ± 0.6
(17) Cl Cl 7.7 ± 0.9 1.3 ± 0.3
(18) H iPr 14 ± 1 0.6 ± 0.2
(19) H tBu 14 ± 1 1.5 ± 0.4