Skip to main content
. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Bioorg Med Chem. 2016 Nov 10;25(3):813–824. doi: 10.1016/j.bmc.2016.11.013

Table 3.

Activity of quinolinol species against RpMetAP1

graphic file with name nihms843186t3.jpg
Compound R1 R2 R3 IC50 (µM) Hill Slope
(20) CH3 H H 1.4 ± 0.1 1.1 ± 0.1
(21) H H H 1.0 ± 0.3 1.2 ± 0.1
(22) H Cl H 0.9 ± 0.1 1.9 ± 0.2
(23) H NO2 H 1.3 ± 0.7 1.7 ± 0.5
(24) H Cl graphic file with name nihms843186t4.jpg 2.5 ± 0.1 1.5 ± 0.1
(25) H NO2 graphic file with name nihms843186t5.jpg 73 ± 38 1.2 ± 0.4
(26) H NO2 graphic file with name nihms843186t6.jpg 16 ± 4 1.0 ± 0.1