Figure 2.

Structure and binding sites of Plasmodium vivax geranylgeranyl diphosphate synthase. A, Structure of PvGGPPS monomer showing helix and loop designations used in the Text. Ligand orientations correspond to PBD ID codes 3LDW, 3PH7 and 5HN9.⁸ B, The a, b and c ligand binding pockets found in PvGGPPS. The d pocket, found only in yeast and human GGPPS, is depicted by the dotted circle.