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Effect of inhibitors on loop 9–10 mobility. A, Loop 9–10 RMSF profiles in the presence of all five inhibitors. B, Stabilization of the 9–10 loop is correlated with inhibitor efficiency (pIC50) for both bisphosphonate and benzoic acid inhibitors, with an R2=0.89. RMSFavg corresponds to average RMSF computed for residues 266 to 280.
