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. Author manuscript; available in PMC: 2017 Sep 13.
Published in final edited form as: Biochemistry. 2016 Sep 1;55(36):5180–5190. doi: 10.1021/acs.biochem.6b00398

Figure 7.

Figure 7

Principal modes of motion control binding pocket accessibility in PvGGPPS. A, Sampling of essential subspace by apo (lilac), Mg2+-bound (blue), GGPP-bound (tan), BPH1186-bound (green), BPH-703-bound GGPPS (pink) or ZOL+IPP-bound (turquoise). B) Open and closed conformations corresponding to PC1 < −50 (left) and PC1 > 20 (right). C) Scheme of GGPPS dynamics as suggested by PCA analysis.