Skip to main content
. Author manuscript; available in PMC: 2017 Feb 21.
Published in final edited form as: Methods Cell Biol. 2016 Apr 4;134:335–368. doi: 10.1016/bs.mcb.2016.03.002

Figure 6.

Figure 6

Regional patterns of cell shape change underlie the emergence of chamber curvatures and are regulated by cardiac function. Confocal projections of live Tg(myl7:egfp)-expressing hearts that also exhibit mosaic expression of Tg(myl7:dsredt4) (red) at 52 hpf. Arrows point to representative cells expressing both dsredt4 and egfp. Ventricular cells in the OC (A) are flattened and elongated, whereas cells in the IC (B) are relatively cuboidal. When blood flow is reduced, as in wea (amhc) mutants (C), OC cells are generally smaller and less elongated. When ventricular contractility is eliminated, as in haf (vmhc) mutants (D), OC cells are considerably enlarged and elongated. Adapted from Auman et al. (2007).