. Author manuscript; available in PMC: 2018 Mar 1.

Published in final edited form as: Hepatology. 2017 Jan 6;65(3):777–788. doi: 10.1002/hep.28926

Table 1.

Liver Transplant Model Variables

Parameter	Min	Base Case	Max	References
Baseline Age	35	50	65	Assumption
*Sustained virologic response rate*
Pre-LT SVR rate	0.700	0.840	0.930	(16-18)
Post-LT SVR rate	0.900	0.950	0.980	(16-18)
*Transition probabilities*
Liver transplant to liver-related death (3 months of 1^st LT)	0.118	0.124	0.129	(33)
Liver transplant to liver-related death (3 months of repeated LT)	0.240	0.264	0.287	(33)
Liver transplant to graft failure (3 months of 1^st LT)	0.161	0.167	0.173	(33)
Liver transplant to graft failure (3 months of repeated LT)	0.287	0.312	0.336	(33)
Sustained virologic response to liver-related death (1^st year)	0.082	0.110	0.137	Figure 10, (34)
Sustained virologic response to liver-related death (subsequent year)	0.024	0.032	0.04	Figure 10, (34)
Sustained virologic response to graft failure	0.037	0.050	0.062	Figure 3, (35)
F0-F2 to liver-related death (1^st year of 1^st LT)	0.118	0.124	0.129	(33)
F0-F2 to liver-related death (Subsequent year of 1^st LT	0.040	0.041	0.042	(33)
F0-F2 to liver-related death (1^st year of repeated LT)	0.240	0.264	0.287	(33)
F0-F2 to liver-related death (Subsequent year of repeated LT)	0.070	0.072	0.075	(33)
F3-F4 to liver-related death (1^st year of 1^st LT)	0.118	0.124	0.129	(33)
F3-F4 to liver-related death (Subsequent year of 1^st LT	0.040	0.041	0.042	(33)
F3-F4 to liver-related death (1^st year of repeated LT)	0.240	0.264	0.287	(33)
F3-F4 to liver-related death (Subsequent year of repeated LT)	0.070	0.072	0.075	(33)
F0–F2 to graft failure (1^st year of 1^st LT)	0.161	0.167	0.173	(33)
F0–F2 to graft failure (1^st year of repeat LT)	0.287	0.312	0.336	(33)
F3–F4 to graft failure (1^st year of 1^st LT)	0.315	0.290	0.525	(36)
F3–F4 to graft failure (1^st year of repeat LT)	0.287	0.312	0.336	(33)
F0–F2 to graft failure (subsequent year of 1^st LT)	0.050	0.051	0.052	(33)
F0–F2 to graft failure (subsequent year of repeat LT)	0.093	0.095	0.098	(33)
F3–F4 to graft failure (subsequent year of 1^st LT)	0.050	0.051	0.052	(33)
F3–F4 to graft failure (subsequent year of repeat LT)	0.093	0.095	0.098	(33)
Graft failure to liver-related death	0.489	0.652	0.815	UNOS data
Graft failure to repeat transplant	0.604	0.805	1.000	UNOS data
F0–F2 to F3–F4	0.040	0.044	0.055	(37)
Decrease in transplant rate due to achieving SVR	0.050	0.080	0.150	Assumption
*Health-related quality-of-life weights*
Transplant waiting list	0.570	0.800	0.990	(38, 39)
Liver transplant	0.370	0.600	0.730	(40)
F0–F2	0.716	0.828	0.865	(39, 40)
F3–F4	0.693	0.801	0.837	(39, 40)
Antiviral Treatment	0.770	0.890	0.930	(40)
Sustained virologic response	0.770	0.890	0.930	(40)
Graft failure	0.570	0.800	0.990	(38, 41)