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. Author manuscript; available in PMC: 2018 Mar 15.

Published in final edited form as: Toxicology. 2017 Jan 25;379:12–21. doi: 10.1016/j.tox.2017.01.016

Alcoholic fatty liver is enhanced in Fgf21^alb-cre mice but is not in Fr1^alb-cre mice. (A) Ethanol induction of FGF21 was blunted in Fgf21^alb-cre mice but was not in Fr1^alb-cre mice (N=5). (B) H&E staining in liver sections shows that alcoholic fatty liver was enhanced in Fgf21^alb-cre mice but not in Fr1^alb-cre mice. (C) Steatosis scores (N=5). (D) Liver TG contents (N=5). *P<0.05, compared to Fr1^fl/fl Control Group. # P<0.05, compared to Fgf21^fl/fl Ethanol Group. ^ P<0.05, compared with Fgf21^fl/fl control group. $ P<0.05, compared to Fr1^alb-cre Control Group. @ P<0.05, compared to Fr1^alb-cre Control Group. Cont, Control; EtOH, Ethanol.

Alcoholic fatty liver is enhanced in Fgf21^alb-cre mice but is not in Fr1^alb-cre mice. (A) Ethanol induction of FGF21 was blunted in Fgf21^alb-cre mice but was not in Fr1^alb-cre mice (N=5). (B) H&E staining in liver sections shows that alcoholic fatty liver was enhanced in Fgf21^alb-cre mice but not in Fr1^alb-cre mice. (C) Steatosis scores (N=5). (D) Liver TG contents (N=5). *P<0.05, compared to Fr1^fl/fl Control Group. # P<0.05, compared to Fgf21^fl/fl Ethanol Group. ^ P<0.05, compared with Fgf21^fl/fl control group. $ P<0.05, compared to Fr1^alb-cre Control Group. @ P<0.05, compared to Fr1^alb-cre Control Group. Cont, Control; EtOH, Ethanol.