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. Author manuscript; available in PMC: 2018 Mar 15.

Published in final edited form as: Toxicology. 2017 Jan 25;379:12–21. doi: 10.1016/j.tox.2017.01.016

Alcoholic fatty liver is more pronounced in Pparα^−/−/Cyp2a5^−/− mice than in Pparα^+/+/Cyp2a5^−/− mice. (A) Ethanol induction of FGF21 was blunted in Pparα^−/−/Cyp2a5^−/− mice (N=4). (B) H&E staining in liver sections shows that alcoholic fatty liver was more pronounced in Pparα^−/−/Cyp2a5^−/− mice than in Pparα^+/+/Cyp2a5^−/− mice. (C) Steatosis scores (N=5). (D) Liver TG contents (N=5). *P<0.05, compared to Pparα^+/+/Cyp2a5^−/− Control Group. # P<0.05, compared to Pparα^−/−/Cyp2a5^−/− Control Group. & P<0.05, compared to Pparα^+/+/Cyp2a5^−/− Ethanol Group. Cont, Control; EtOH, Ethanol.

Alcoholic fatty liver is more pronounced in Pparα^−/−/Cyp2a5^−/− mice than in Pparα^+/+/Cyp2a5^−/− mice. (A) Ethanol induction of FGF21 was blunted in Pparα^−/−/Cyp2a5^−/− mice (N=4). (B) H&E staining in liver sections shows that alcoholic fatty liver was more pronounced in Pparα^−/−/Cyp2a5^−/− mice than in Pparα^+/+/Cyp2a5^−/− mice. (C) Steatosis scores (N=5). (D) Liver TG contents (N=5). *P<0.05, compared to Pparα^+/+/Cyp2a5^−/− Control Group. # P<0.05, compared to Pparα^−/−/Cyp2a5^−/− Control Group. & P<0.05, compared to Pparα^+/+/Cyp2a5^−/− Ethanol Group. Cont, Control; EtOH, Ethanol.