Table 4.
Kendall's tau estimates for the dependence between the times to first and second CRCs, penetrance estimates of the first CRC by age 70, 𝒫1(70), and 10-year risk estimates of the second CRC given the age at first CRC T1, 𝒫2(10; T1), for different types of MMR gene mutation based on the log-logistic regression model; SEbs are bootstrap standard errors obtained from 1000 bootstrapped family samples
| Gene Mutation | no. of families | Kendall's τ | Male carriers | Female carriers | ||||
|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||
| 𝒫1(70) | 𝒫2(10; 40) | 𝒫2(10; 50) | 𝒫1(70) | 𝒫2(10; 40) | 𝒫2(10; 50) | |||
| MLH1 | 278 | 0.1092 | 72.23% | 16.68% | 19.13% | 52.25% | 12.46% | 14.87% |
| SEb | 0.0328 | 3.26% | 2.71% | 3.01% | 3.25% | 2.23% | 2.68% | |
|
| ||||||||
| MSH2 | 342 | 0.0372 | 57.66% | 13.10% | 13.78% | 52.79% | 15.10% | 15.91% |
| SEb | 0.0217 | 2.96% | 1.78% | 1.90% | 3.12% | 2.08% | 2.22% | |
|
| ||||||||
| MSH6 | 101 | 0.0084 | 30.46% | 4.91% | 4.99% | 15.81% | 9.34% | 9.50% |
| SEb | 0.0705 | 5.32% | 2.40% | 2.60% | 3.12% | 3.55% | 3.91% | |
|
| ||||||||
| ALL* | 781 | 0.0713 | 54.61% | 12.00% | 13.25% | 43.32% | 13.08% | 14.56% |
| SEb | 0.0192 | 2.22% | 1.31% | 1.43% | 1.96% | 1.28% | 1.41% | |
*
ALL includes MLH1, MSH2, MSH6, MSP2 and EPCAM