Fig. 3.

Regression plots showing functional connectivity in the inferior fronto-occipital fasciculus (IFOF)–connected regions of interest of the DMN as a function of WMHr in the IFOF. The regression lines for each group (colored) and the whole sample (solid black line) and the standard error of the estimate (shaded area) are shown. Higher WMHr in the IFOF was associated with lower FC in the gray matter projection area of the IFOF. Statistical outliers (>3 standard deviation from group mean) have been removed for purposes of the current graph (robust regression model accounted for outliers in the regression analysis). Abbreviation: WMHr, ratio between the WMH volume and total white matter.