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. 2017 Feb 22;11:29. doi: 10.3389/fnbeh.2017.00029

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Copyright © 2017 Holgate, Shariff, Mu and Bartlett.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Experimental timeline for the intermittent access 2-bottle choice (IA2BC) and drinking in the dark (DID) models. Five week old male Wistar rats are given 1 week to habituate to the experimental housing conditions before commencing consumption of 20% ethanol or 5% sucrose using the IA2BC (A) or DID (B) models. Rats consuming ethanol using the DID model also had blood collected for blood ethanol concentration (BEC) measurement after 10 weeks of drinking sessions. After 12 weeks of ethanol or sucrose consumption, DID rats received 2 once weekly injections of vehicle or 2 mg/kg varenicline in pseudorandom order, such that each rat served as their own control.