Table 2.
Genotyping frequencies and summary results of the association studies.
| Locus | Marker (rs#) and gene | Genotype/allele | Number of Individuals (Genotypes) or Alleleswith less enamel loss | Number of Individuals (Genotypes) or Alleleswith more enamel loss | p-value | Number of Individuals (Genotypes) or Alleleswith less enamel loss | Number of Individuals (Genotypes) or Alleleswith more enamel loss | p-value | Number of Individuals (Genotypes) or Alleleswith less enamel loss | Number of Individuals (Genotypes) or Alleleswith more enamel loss | p-value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | After creation of artificial lesion | After remineralization | |||||||||
| 5q13.2 | 27565 (PART1) | CC | 3 | 4 | 0.68# | 2 | 6 | 0.77# | 5 | 5 | 0.89# |
| CT | 13 | 14 | 11 | 19 | 16 | 18 | |||||
| TT | 1 | 3 | 1 | 3 | 4 | 3 | |||||
| C | 19 | 22 | 0.76## | 15 | 31 | 0.88## | 26 | 28 | 0.85## | ||
| T | 15 | 20 | 13 | 25 | 24 | 24 | |||||
| 4700418 (ZSWIM6) | CC | 5 | 7 | 0.71# | 3 | 9 | 0.64# | 7 | 7 | 0.98# | |
| CG | 7 | 6 | 7 | 10 | 11 | 11 | |||||
| GG | 5 | 8 | 4 | 9 | 7 | 8 | |||||
| C | 17 | 20 | 0.84## | 13 | 28 | 0.76## | 25 | 25 | 0.85## | ||
| G | 17 | 22 | 15 | 28 | 25 | 27 | |||||
| 875459 (CCNB1) | GG | 5 | 5 | 0.69# | 2 | 8 | 0.3# | 5 | 0 | 0.32# | |
| GT | 11 | 13 | 9 | 18 | 18 | 2 | |||||
| TT | 1 | 3 | 3 | 2 | 2 | 17 | |||||
| G | 21 | 23 | 0.84## | 13 | 34 | 0.21## | 28 | 26 | 0.54## | ||
| T | 13 | 19 | 15 | 22 | 22 | 26 | |||||
| 6862039 (BTF3) | AA | 1 | 0 | 0.22# | 1 | 0 | 0.1# | 2 | 0 | 0.32# | |
| AT | 2 | 1 | 2 | 1 | 4 | 2 | |||||
| TT | 8 | 17 | 7 | 22 | 17 | 17 | |||||
| A | 4 | 1 | 0.04## | 4 | 1 | 0.01## | 8 | 2 | 0.09## | ||
| T | 18 | 35 | 16 | 45 | 38 | 36 | |||||
| Aquaporin | 467323 (AQP2) | AA | 2 | 3 | 0.88# | 1 | 4 | 0.5# | 1 | 4 | 0.32# |
| 12q13.12 | AG | 8 | 11 | 6 | 15 | 12 | 13 | ||||
| GG | 7 | 7 | 7 | 9 | 12 | 9 | |||||
| A | 12 | 17 | 0.64## | 8 | 23 | 0.26## | 14 | 21 | 0.19## | ||
| G | 22 | 25 | 20 | 33 | 36 | 31 | |||||
| 2878771 (AQP2) | AA | 2 | 0 | 0.26# | 1 | 1 | 0.83# | 2 | 0 | 0.3# | |
| AG | 5 | 8 | 5 | 9 | 7 | 7 | |||||
| GG | 10 | 13 | 8 | 18 | 15 | 19 | |||||
| A | 9 | 8 | 0.44## | 7 | 11 | 0.57## | 11 | 7 | 0.22## | ||
| G | 25 | 34 | 21 | 45 | 37 | 45 | |||||
| 10875989 (AQP2) | AA | 2 | 3 | 0.9# | 1 | 4 | 0.26# | 1 | 4 | 0.18# | |
| AG | 9 | 12 | 6 | 17 | 12 | 15 | |||||
| GG | 6 | 6 | 7 | 7 | 12 | 7 | |||||
| A | 13 | 18 | 0.68## | 8 | 25 | 0.16## | 14 | 23 | 0.09## | ||
| G | 21 | 24 | 20 | 31 | 36 | 29 | |||||
| 3759129 (AQP5) | AA | 8 | 13 | 0.36# | 5 | 19 | 0.07# | 14 | 14 | 0.91# | |
| AG | 6 | 5 | 6 | 6 | 6 | 8 | |||||
| GG | 1 | 0 | 1 | 0 | 1 | 1 | |||||
| A | 22 | 31 | 0.19## | 16 | 44 | 0.03## | 34 | 36 | 0.75## | ||
| G | 8 | 5 | 8 | 6 | 8 | 10 | |||||
| 296763 (AQP5) | AA | 2 | 0 | 0.25# | 1 | 1 | 0.12# | 0 | 2 | 0.21# | |
| AG | 6 | 7 | 7 | 6 | 11 | 7 | |||||
| GG | 9 | 14 | 6 | 21 | 14 | 17 | |||||
| A | 10 | 7 | 0.18## | 9 | 8 | 0.05## | 11 | 11 | 1.0# | ||
| G | 24 | 35 | 19 | 48 | 39 | 41 | |||||
| 1996315 (AQP6) | AA | 0 | 0 | 0.52# | 0 | 0 | 0.93# | 0 | 0 | 0.23# | |
| AG | 3 | 2 | 3 | 5 | 3 | 6 | |||||
| GG | 12 | 15 | 11 | 17 | 20 | 16 | |||||
| A | 3 | 2 | 0.54## | 3 | 5 | 0.93## | 3 | 6 | 0.26## | ||
| G | 27 | 32 | 25 | 39 | 43 | 38 | |||||
#
p-value of the comparison of genotyping frequencies between individuals with enamel loss below and above the mean of the studied group. Chi-square or Fisher's exact tests with 2 degrees of freedom.
##
p-value of the comparison of allele frequencies between individuals with enamel loss below and above the mean of the studied group. Chi-square or Fisher's exact tests with 1 degree of freedom.