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. 2016 Nov 29;101(6):2319–2331. doi: 10.1007/s00253-016-7993-7

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Scheme 3 — Conversions of a omeprazole (5) to its proposed monohydroxylation metabolite (6) and b rosiglitazone (7) and the proposed demethylation (8) and N-oxidation metabolites (9)