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. 2004 Dec;15(12):5268–5282. doi: 10.1091/mbc.E04-07-0591

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Copyright © 2004, The American Society for Cell Biology

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Figure 10. — ErbB2 has a distribution similar to that of internalized trastuzumab and is sorted GA to bilayered coats on endosomes in SKBr3 (A, C, and D) and BT474 (B) cells. (A) Surface ErbB2 is concentrated on microvillus-like protrusions (asterisks) and infrequently observed in clathrin-coated pits (arrow). (B) Internal nonbiosynthetic ErbB2 is localized mainly on small tubulovesicular membranes (arrows). (C) GA induces redistribution of ErbB2 on endosomal limiting membranes to bilayered coats (arrowheads) in trastuzumab-treated cells. (D) Sorting of ErbB2 to bilayered coats (arrowheads) occurs after only 45 min of GA treatment. EE, early endosome. Scale bars, 200 nm.