Figure 1.

Schematic diagrams of ARVCF, ZO-1, and ZO-2. (A) Domain structure of ARVCF. The amino acid substitutions that abolish binding to PDZ-domains [ARVCF(ΔP); black diamond] and the deletion of the armadillo domains (ARVCF(ΔA) are indicated. (B) Domain organization of ZO-1. Truncated ZO-1 and ZO-2 proteins carrying only the three PDZ domains (ZO-1 PDZ, ZO-2 PDZ) are depicted and amino acid substitutions in the PDZ domains of ZO-1 that abolish binding to C-terminal peptide [ZO-1 PDZ(mut), white diamonds] and the deletion of the nuclear localization signal in ZO-2 PDZ (ZO-2 (ΔNLS) are shown. Diagrams are not to scale.