Table 2.

Shared epitope frequency and HLA-DRB1 alleles frequency in Tunisian and French RA.

Alleles HLA-DRB1	Tunisian RA Allele number (N = 264)	Tunisian allele frequency (%)	French RA Allele number (N = 346)	French allele frequency (%)	OR [95% CI]	p value	pvalue∗
#DRB1∗01:XX	16	6.06	59	22.35	0.31 [0–0.51]	1.6E−05	35.2E−05
DRB1∗01:03	0	0.00	1	0.38	0 [0–4.55]	0.32	NS
DRB1∗03:XX	42	15.91	15	5.68	4.17 [2.48–+∞]	1E−06	22E−06
#DRB1∗04:01	11	4.17	48	18.18	0.26 [0–0.47]	1.5E−05	33E−05
DRB1∗04:02	1	0.38	1	0.38	1.31 [0.20–+∞]	0.39	NS
DRB1∗04:03	3	1.14	4	1.52	0.98 [0–3.23]	0.51	NS
#DRB1∗04:04	8	3.03	30	11.36	0.32 [0–0.64]	0.001	0.0022
#DRB1∗04:05	19	7.20	12	4.55	2.15 [1.16–+∞]	0.01	NS
DRB1∗04:06	6	2.27	0	0.00	+∞ [2.49–+∞]	0.002	0.044
DRB1∗04:07	0	0.00	1	0.38	0 [0–4.56]	0.32	NS
#DRB1∗04:08	3	1.14	9	3.41	0.43 [0–1.27]	0.11	NS
DRB1∗04:11	1	0.38	0	0.00	+∞ [0.37–+∞]	0.18	NS
DRB1∗07:XX	41	15.53	46	17.42	1.19 [0.81–+∞]	0.21	NS
DRB1∗08:XX	3	1.14	1	0.38	3.96 [0.68–+∞]	0.11	NS
DRB1∗09:XX	1	0.38	2	0.76	0.65 [0–3.98]	0.41	NS
#DRB1∗10:01	33	12.50	13	4.92	3.65 [2.09–+∞]	2.3E−05	50.6E−05
DRB1∗11:XX	19	7.20	25	9.47	0.99 [0–1.66]	0.5	NS
DRB1∗12:XX	0	0.00	5	1.89	0 [0–0.83]	0.03	NS
DRB1∗13:XX	40	15.15	24	9.09	2.39 [1.52–+∞]	0.0005	0.011
DRB1∗14:XX	4	1.52	4	1.52	1.31 [0.43–+∞]	0.33	NS
DRB1∗15:XX	12	4.55	33	12.50	0.45 [0–0.80]	0.009	NS
DRB1∗16:XX	1	0.38	13	4.92	0.09 [0–0.49]	0.002	0.044

^#Shared epitope, XX means all known alleles, DRB1^∗14: XX apart from DRB1^∗14:02

^∗ p value corrected with Bonferroni correction.

NS: not significant.