Table 5.
TMEM187-IRAK1 genotypes for samples of RA and healthy controls in Tunisian and French female populations.
| Gene/SNPs | Population | Genotype | Controls (%) |
RA cases (%) |
OR (95% CI) | p values |
|---|---|---|---|---|---|---|
| TMEM 187 rs13397 | Tunisian | GG | 92 (70) | 66 (53) | 0.48 (0.12–0.73) | 0.0025 |
| AG | 23 (18) | 46 (41) | ||||
| AA | 16 (12) | 7 (6) | ||||
| French | GG | 220 (65) | 131 (45) | 0.45 (0.21–0.59) | 1.0e − 6 | |
| AG | 97 (28) | 137 (47) | ||||
| AA | 23 (7) | 21 (8) | ||||
|
| ||||||
| IRAK 1 rs1059703 | Tunisian | CC | 15 (11) | 9 (7) | 0.46 (0.13–0.71) | 0.0017 |
| CT | 27 (21) | 51 (43) | ||||
| TT | 89 (68) | 59 (50) | ||||
| French | CC | 27 (8) | 34 (12) | 0.36 (0.15–0.47) | 1.0e − 6 | |
| CT | 85 (25) | 133 (46) | ||||
| TT | 228 (67) | 122 (42) | ||||
|
| ||||||
| IRAK 1 rs1059702 | Tunisian | CC | 81 (62) | 62 (52) | 0.67 (0.18–1.02) | 0.0608 |
| CT | 34 (26) | 43 (36) | ||||
| TT | 16 (12) | 14 (12) | ||||
| French | CC | 237 (70) | 157 (54) | 0.52 (0.24–0.68) | 3.7e − 5 | |
| CT | 83 (24) | 100 (35) | ||||
| TT | 20 (6) | 32 (11) | ||||
∗ p values compared genotypes according to the dominant/recessive model.