TABLE 3.
Mixed-effects linear model of LAZ from age 0 to 6 mo in African HIV-exposed uninfected children in the Kesho Bora RCT1
| Fixed effects | β02 | P | β13 | P |
| Age, mo | 0.09 ± 0.03 | 0.003 | — | |
| Infant feeding | 0.73 | 0.001 | ||
| Never breastfeeding | −0.03 ± 0.11 | 0.79 | 0.073 ± 0.020 | <0.001 |
| EBF <3 mo | 0.05 ± 0.09 | 0.61 | 0.012 ± 0.017 | 0.45 |
| EBF ≥3 mo | 0 | 0 | ||
| RCT arm | 0.015 | 0.008 | ||
| Triple antiretroviral | −0.18 ± 0.08 | 0.015 | 0.037 ± 0.014 | 0.008 |
| Short course | 0 | 0 | ||
| Child sex | 0.60 | 0.047 | ||
| Male | −0.04 ± 0.08 | 0.60 | −0.028 ± 0.014 | 0.047 |
| Female | 0 | 0 | ||
| Study site | 0.005 | 0.008 | ||
| Bobo Dioulasso | 0.30 ± 0.12 | 0.012 | −0.028 ± 0.022 | 0.19 |
| Mombasa | 0.26 ± 0.11 | 0.018 | −0.042 ± 0.020 | 0.041 |
| Nairobi | −0.24 ± 0.20 | 0.22 | −0.123 ± 0.035 | <0.001 |
| Somkhele | 0.16 ± 0.14 | 0.26 | −0.011 ± 0.024 | 0.66 |
| Durban | 0 | 0 | ||
| Maternal BMI,4 kg/m2 | <0.001 | 0.08 | ||
| <20 | −0.42 ± 0.15 | 0.005 | 0.029 ± 0.028 | 0.29 |
| 20–22.49 | −0.47 ± 0.12 | <0.001 | 0.030 ± 0.021 | 0.16 |
| 22.5–25 | −0.06 ± 0.09 | 0.50 | −0.017 ± 0.17 | 0.30 |
| >25 | 0 | 0 | ||
| Maternal height, cm | <0.001 | 0.30 | ||
| <155 | −0.45 ± 0.12 | <0.001 | −0.031 ± 0.022 | 0.16 |
| 155–159.9 | −0.18 ± 0.11 | 0.11 | −0.017 ± 0.021 | 0.40 |
| 160–164.9 | −0.02 ± 0.11 | 0.88 | 0.002 ± 0.022 | 0.93 |
| ≥165 | 0 | 0 | ||
| Maternal education | 0.48 | 0.27 | ||
| None | 0.12 ± 0.14 | 0.38 | −0.017 ± 0.026 | 0.51 |
| Primary | 0.10 ± 0.09 | 0.27 | 0.019 ± 0.017 | 0.27 |
| Secondary | 0 | 0 | ||
| Maternal CD4+ cell count/mm3 | 0.77 | 0.09 | ||
| 200–349 | −0.02 ± 0.08 | 0.77 | −0.025 ± 0.014 | 0.09 |
| 350–500 | 0 | 0 | ||
| Wealth tertile5 | 0.20 | 0.042 | ||
| Lower | −0.16 ± 0.09 | 0.10 | −0.009 ± 0.017 | 0.59 |
| Middle | −0.13 ± 0.09 | 0.17 | 0.032 ± 0.017 | 0.06 |
| Upper | 0 | 0 |
Values are means ± SEs. n = 728. EBF, exclusive breastfeeding; LAZ, length-for-age z score; RCT, randomized controlled trial.
The β0 coefficient represents the estimated mean difference in LAZ at age 2 d.
The β1 coefficient represents the estimated mean change (slope) in LAZ/mo from age 2 d to 6 mo.
Maternal BMI was measured during the first 2 mo postpartum.
Wealth tertiles were site specific.