TABLE 2.
HRs (95% CIs) for colorectal cancer incidence by quartile of E-DII score for all participants and by sex, Multiethnic Cohort, 1993–20101
| E-DII | Person-years (cases) | Minimally adjusted HR (95%CI)2 | Fully adjusted HR (95%CI)3 |
| All participants | |||
| Quartile 1 (−6.64 to −3.66) | 705,288 (1090) | 1.00 (Ref) | 1.00 (Ref) |
| Quartile 2 (−3.65 to −2.32) | 702,448 (1055) | 1.03 (0.94, 1.18) | 1.02 (0.93, 1.11) |
| Quartile 3 (−2.31 to −0.53) | 700,933 (1028) | 1.03 (0.95, 1.13) | 0.99 (0.91, 1.08) |
| Quartile 4 (−0.52 to 4.95) | 697,966 (1215) | 1.31 (1.20, 1.43) | 1.21 (1.11, 1.32) |
| Continuous | — | — | 1.04 (1.02, 1.06) |
| P-trend | — | — | <0.01 |
| Men | |||
| Quartile 1 (−6.64 to −3.66) | 211,424 (381) | 1.00 (Ref) | 1.00 (Ref) |
| Quartile 2 (−3.65 to −2.32) | 264,408 (476) | 1.08 (0.94, 1.23) | 1.06 (0.92, 1.21) |
| Quartile 3 (−2.31 to −0.53) | 335,686 (613) | 1.15 (1.01, 1.31) | 1.09 (0.95, 1.24) |
| Quartile 4 (−0.52 to 4.95) | 412,418 (827) | 1.39 (1.23, 1.58) | 1.28 (1.13, 1.45) |
| Continuous | — | — | 1.05 (1.03, 1.07) |
| P-trend | — | — | <0.01 |
| Women | |||
| Quartile 1 (−6.64 to −3.66) | 493,864 (709) | 1.00 (Ref) | 1.00 (Ref) |
| Quartile 2 (−3.65 to −2.32) | 438,040 (579) | 1.00 (0.90, 1.12) | 1.00 (0.90, 1.12) |
| Quartile 3 (−2.31 to −0.53) | 365,247 (415) | 0.94 (0.83, 1.06) | 0.91 (0.81, 1.03) |
| Quartile 4 (−0.52 to 4.95) | 285,548 (388) | 1.26 (1.11, 1.43) | 1.16 (1.02, 1.33) |
| Continuous | — | — | 1.02 (1.00, 1.05) |
| P-trend | — | — | 0.13 |
1
n = 190,963. E-DII, energy-adjusted Dietary Inflammatory Index; Ref, reference.
2
Age, sex, and race included in STRATA statement.
3
Self-reported previous diagnosis of diabetes, asthma, and heart attack; use of supplements; smoking status; family history of colon cancer; education; hormone (i.e., estrogen or progesterone) use; aspirin use; and BMI with age, sex, and race/ethnicity in the STRATA statement. Sex-stratified models did not include sex in the STRATA statement.