TABLE 4.
HRs (95% CIs) for colorectal cancer incidence by E-DII quartile for all participants and stratified by tumor location or stage, Multiethnic Cohort, 1993–20101
| E-DII | Person-years (cases)2 | Minimally adjustedHR (95%CI)3 | Fully adjustedHR (95%CI)4 |
| Colon | |||
| Quartile 1 (−6.64 to −3.66) | 703,565 (855) | 1.00 (Ref) | 1.00 (Ref) |
| Quartile 2 (−3.65 to −2.32) | 700,803 (846) | 1.06 (0.96, 1.16) | 1.05 (0.96, 1.16) |
| Quartile 3 (−2.31 to −0.53) | 699,157 (790) | 1.04 (0.94, 1.15) | 1.00 (0.91, 1.11) |
| Quartile 4 (−0.52 to 4.95) | 695,379 (881) | 1.27 (1.15, 1.41) | 1.20 (1.09, 1.33) |
| Continuous | — | — | 1.04 (1.02, 1.06) |
| P-trend | — | — | <0.01 |
| Rectum or both | |||
| Quartile 1 (−6.64 to −3.66) | 698,137 (235) | 1.00 (Ref) | 1.00 (Ref) |
| Quartile 2 (−3.65 to −2.32) | 695,685 (209) | 0.91 (0.76, 1.10) | 0.90 (0.74, 1.08) |
| Quartile 3 (−2.31 to −0.53) | 694,310 (238) | 1.02 (0.85, 1.22) | 0.95 (0.79, 1.14) |
| Quartile 4 (−0.52 to 4.95) | 690,734 (334) | 1.43 (1.20, 1.70) | 1.22 (1.02, 1.47) |
| Continuous | — | — | 1.05 (1.01, 1.08) |
| P-trend | — | — | 0.01 |
| Local | |||
| Quartile 1 (−6.64 to −3.66) | 700,359 (485) | 1.00 (Ref) | 1.00 (Ref) |
| Quartile 2 (−3.65 to −2.32) | 697,901 (474) | 1.03 (0.91, 1.18) | 1.02 (0.90, 1.17) |
| Quartile 3 (−2.31 to −0.53) | 696,331 (459) | 1.03 (0.90, 1.17) | 0.99 (0.87, 1.14) |
| Quartile 4 (−0.52 to 4.95) | 692,386 (519) | 1.23 (1.08, 1.40) | 1.14 (1.00, 1.31) |
| Continuous | — | — | 1.03 (1.01, 1.06) |
| P-trend | — | — | 0.07 |
| Regional | |||
| Quartile 1 (−6.64 to −3.66) | 699,778 (422) | 1.00 (Ref) | 1.00 (Ref) |
| Quartile 2 (−3.65 to −2.32) | 697,122 (395) | 1.00 (0.87, 1.15) | 0.99 (0.86, 1.14) |
| Quartile 3 (−2.31 to −0.53) | 695,627 (388) | 1.02 (0.89, 1.18) | 0.97 (0.85, 1.12) |
| Quartile 4 (−0.52 to 4.95) | 691,731 (466) | 1.34 (1.17, 1.54) | 1.24 (1.08, 1.43) |
| Continuous | — | — | 1.04 (1.01, 1.06) |
| P-trend | — | — | <0.01 |
| Distant | |||
| Quartile 1 (−6.64 to −3.66) | 697,673 (149) | 1.00 (Ref) | 1.00 (Ref) |
| Quartile 2 (−3.65 to −2.32) | 695,386 (171) | 1.19 (0.96, 1.49) | 1.19 (0.95, 1.49) |
| Quartile 3 (−2.31 to −0.53) | 693,841 (159) | 1.14 (0.91, 1.43) | 1.09 (0.87, 1.38) |
| Quartile 4 (−0.52 to 4.95) | 689,836 (200) | 1.53 (1.22, 1.91) | 1.40 (1.11, 1.77) |
| Continuous | — | — | 1.07 (1.03, 1.11) |
| P-trend | — | — | 0.01 |
1
n = 190,963. E-DII, energy-adjusted Dietary Inflammatory Index; Ref, reference.
2
A total of 101 cases were missing stage data and were excluded from this analysis.
3
Age, sex, and race included in STRATA statement.
4
Self-reported previous diagnosis of diabetes, asthma, and heart attack; use of supplements; smoking status; family history of colon cancer; education; hormone (i.e., estrogen or progesterone) use; aspirin use; and BMI with age, sex, and race/ethnicity in the STRATA statement.