FIGURE 1.

Patterns of metabolite response to diet. Examples of 8 metabolites demonstrating significant differential responses to 3 weight-loss maintenance diets administered to 21 young adults in a randomized crossover trial. Metabolites were selected to illustrate contrasting patterns of responses. Vertical axes show relative change from pre–weight loss metabolite concentration. Boxes indicate means and 95% CIs. Lines connect covariate-adjusted data for individual participants, omitting outliers detected by robust regression procedure. Bracketed diets did not differ significantly according to repeated-measures ANOVA on log-transformed, covariate-adjusted metabolite concentrations. P tests the hypothesis of equal mean concentration across all 3 diets, adjusted for multiple comparisons by Holm step-down procedure. Adj, adjusted; LF, low-fat diet; LGI, low–glycemic index diet; TAG, triacylglycerol; VLC, very–low carbohydrate diet.