Table 3.
Interaction analysis of -94 ins/del ATTG polymorphism with inflammatory markers
| Inflammatory marker | Groups | NG (n = 100) | DM (n = 100) | DM-CRD (n = 100) | P value |
| uMCP-1 (pg/mg creatinine) | Total | 130.00 ± 42.22 | 271.00 ± 120.01 | 5632.70 ± 1007.20ab | |
| del/del | 85.1 ± 9.2 | 200.6 ± 66.5 | 4609.9 ± 900.6 | P = 0.026 | |
| ins/del | 110.9 ± 15.6 | 278.9 ± 105.9 | 5879.9 ± 1016.3 | ||
| ins/ins | 166.8 ± 26.8 | 302.2 ± 100.1 | 6405.1 ± 1550.6 | ||
| Plasma TNF-α (pg/mL) | Total | 15.55 ± 2.22 | 16.51 ± 3.75 | 21.38 ± 3.67ab | |
| del/del | 8.27 ± 1.06 | 10.21 ± 1.32 | 17.31 ± 1.17 | P = 0.030 | |
| ins/del | 11.55 ± 0.05 | 14.05 ± 0.18 | 19.31 ± 0.44 | ||
| ins/ins | 15.08 ± 1.15 | 16.36 ± 1.20 | 23.12 ± 0.70 |
a
Significantly different from Normoglycemic at P < 0.001;
b
Significantly different from diabetic patients without nephropathy at P < 0.001. uMCP-1 levels, plasma TNF-α levels are expressed as mean + SD. NG: Normoglycemic; DM: Diabetes mellitus without nephropathy; DM-CRD: Diabetic nephropathy.