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. 2017 Feb 22;7:42996. doi: 10.1038/srep42996

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Copyright © 2017, The Author(s)

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(A upper) The expression of CCR7 in immature DC-exos and mature DC-exos. When we used siRNA to down-regulate mature DCs’ expression of CCR7, its expression in mature DC-exos was also down-regulated. A total of 10ug exosomal protein was loaded into every lane. (A lower) The accumulation of immature DC-exos, mature DC-exos and mature DC-exos with down-regulated CCR7 in liver and spleen. Representative images of 3 dependent studies. (B) Immature DC-exos, mature DC-exos and mature DC-exos with down-regulated CCR7 were injected to mice. After 24 hours, the serum was collected for detection of IL-6 and TNF-α by Elisa (n = 5–6). *p < 0.05, **p < 0.01, ***p < 0.001.