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. 2017 Feb 22;7:43030. doi: 10.1038/srep43030

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Principal component analysis (PCA) of all the data (n = 24 sheep, 10 control, 14 HD; n = 130 metabolites; n = 13 time points). Samples are coloured by genotype (black, control; red, HD); (b) OPLS-DA model showing separation by genotype. (c) OPLS-DA loading plot of control vs HD. Negative p(corr) values represent decreased and positive p(corr) values represent increased metabolite concentrations in HD compared to control sheep. The metabolite bars are colour coded according to metabolite class as follows: amino acids and biogenic amines (blue); acylcarnitines (green); lysophosphatidylcholine acyl (lyso PC a) (dark orange); phosphatidylcholine diacyl (PC aa) (yellow); phosphatidylcholine acyl-akyl (PC ae) (light orange); sphingolipids (SM) (brown). For further details on metablolites, see text and Suppl. Table 2.