Table 1.
Comparison of HE4 and CA125 serum concentrations in patients considering selected risk factors in different stages of EC
| Risk factor | All stages of EC | Stage I EC | Stages II-III EC | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N (%) | HE4 | CA125 | N (%) | HE4 | CA125 | N (%) | HE4 | CA125 | ||||||||
| M | SL | M | SL | M | SL | M | SL | M | SL | M | SL | |||||
| Age | < 60 years > 60 years |
12 (26) 34 (74) |
82.80 100.7 |
0.26 | 15.99 20.43 |
0.94 | 8 (23) 26 (77) |
47.00 94.90 |
0.06 | 14.08 15.85 |
0.51 | 4 (33) 8 (67) |
517.8 204.15 |
0.68 | 159.3 41.52 |
0.28 |
| Menopause | No Yes |
4 (9) 42 (91) |
460.25 99.35 |
0.83 | 104.89 18.09 |
0.16 | 2 (6) 32 (94) |
45.85 94.90 |
0.05 | 15.59 15.72 |
0.97 | 2 (17) 10 (83) |
1177.4 175.15 |
0.03 | 693.8 41.52 |
0.03 |
| BMI | 18.5– 24,99 ≥ 25 |
8 (18) 37 (82) |
94.90 101.30 |
0.35 | 22.65 16.05 |
0.21 | 7 (21) 27 (79) |
93.20 90.20 |
0.35 | 22.30 11.39 |
0.06 | 1 (9) 10 (91) |
259.9 202.7 |
0.72 | 77.40 41.52 |
0.90 |
| Hypertension | No Yes |
18 (39) 28 (61) |
112.75 98.25 |
0.98 | 20.30 16.97 |
0.28 | 12 (35) 22 (65) |
75.90 93.40 |
0.30 | 15.91 13.60 |
0.65 | 6 (50) 6 (50) |
285.75 148.3 |
0.18 | 101.2 40.86 |
0.31 |
| Diabetes | No Yes |
38 (83) 8 (17) |
98.25 148.80 |
0.45 | 18.43 13.85 |
0.57 | 28 (82) 6 (18) |
91.70 103.65 |
0.61 | 15.93 9.55 |
0.38 | 10 (83) 2 (17) |
202.7 218.25 |
0.75 | 41.52 71.72 |
0.75 |
| Menarche | Early Normal |
3 (6) 43 (94) |
100.10 98.60 |
0.73 | 26.43 16.17 |
0.22 | 2 (6) 32 (94) |
99.00 89.70 |
0.64 | 24.37 15.33 |
0.25 | 1 (8) 11 (92) |
173.7 231.7 |
0.83 | 125.0 54.00 |
0.66 |
| Onset of menopause | Normal Late |
36 (86) 6 (14) |
97.25 174.25 |
0.08 | 16.97 53.22 |
0.22 | 29 (91) 3 (9) |
93.20 123.5 |
0.49 | 15.64 107.0 |
0.38 | 7 (70) 3 (30) |
173.7 259.9 |
0.26 | 54.00 29.04 |
0.83 |
| Positive family history of certain cancers | No Yes |
36 (78) 10 (22) |
100.70 93.90 |
0.64 | 18.43 15.93 |
0.90 | 26 (77) 8 (23) |
94.90 81.20 |
0.46 | 15.91 13.04 |
0.73 | 10 (83) 2 (17) |
202.7 834.8 |
0.36 | 41.52 630.02 |
0.27 |
EC – endometrial cancer; N – number of patients; M – median; SL – significance level; BMI – body mass index