Table 2.
Comparison of HE4 and CA125 serum concentrations considering histological grading
| Risk factor | Histological grade G1 | Histological grade 2–3 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| N (%) | HE4 | CA125 | N (%) | HE4 | CA125 | ||||||
| M | SL | M | SL | M | SL | M | SL | ||||
| Age | < 60 years > 60 years |
9 (26) 25 (74) |
49.00 96.60 |
0.03 | 15.80 18.56 |
0.56 | 3 (25) 9 (75) |
861.90 110.8 |
0.06 | 193.6 22.3 |
0.37 |
| Menopause | No Yes |
2 (6) 32 (94) |
45.85 94.9 |
0.05 | 15.59 17.17 |
0.85 | 2 (17) 10 (83) |
1177.4 115.4 |
0.03 | 693.8 20.09 |
0.03 |
| BMI | 18.5–24.99 ≥ 25 |
6 (18) 27 (82) |
68.55 90.20 |
0.30 | 19.59 15.01 |
0.24 | 2 (17) 10 (83) |
156.55 120.5 |
0.75 | 59.3 22.8 |
0.75 |
| Hypertension | No Yes |
13 (38) 21 (62) |
67.7 96.6 |
0.15 | 15.64 18.56 |
0.88 | 5 (42) 7 (58) |
311.6 110.8 |
0.07 | 96.3 12.8 |
0.03 |
| Diabetes | No Yes |
28 (82) 6 (18) |
89.7 197.15 |
0.159 | 16.11 37.66 |
0.94 | 10 (83) 2 (17) |
166.5 103.65 |
0.48 | 28.38 13.85 |
0.27 |
| Menarche | Early Normal |
2 (6) 32 (94) |
135.8 89.70 |
0.47 | 75.72 15.93 |
0.10 | 1 (8) 11 (92) |
100.1 121 |
0.50 | 22.3 27.72 |
0.99 |
| Onset of menopause | Normal Late |
28 (87) 4 (13) |
91.7 174.25 |
0.23 | 15.93 92.2 |
0.18 | 8 (80) 2 (20) |
115.4 206.45 |
0.53 | 20.09 20.92 |
0.88 |
| Positive family history of certain cancers | No Yes |
25 (73) 9 (27) |
93.2 89.20 |
0.67 | 18.29 15.8 |
0.70 | 11 (92) 1 (8) |
120.0 1493.0 |
0.16 | 22.3 1194 |
0.16 |
EC – endometrial cancer; N – number of patients; M – median; SL – significance level