Table 3.
Adverse events (AE) [n (%)]
| AE | TACE plus S-1 (n = 101) | TACE mono-therapy (n = 75) | P value |
|---|---|---|---|
| Abdominal pain | 71 (70.3) | 52 (69.3) | 0.890 |
| Anorexia | 25 (24.8) | 9 (12.0) | 0.034 |
| Nausea | 40 (39.6) | 17 (22.7) | 0.018 |
| Diarrhea | 0 (0.0) | 1 (1.3) | NA |
| Hyperbilirubinemia | 61 (60.4) | 47 (62.7) | 0.760 |
| Transaminase elevation | 65 (64.4) | 46 (61.3) | 0.681 |
| Anemia | 30 (29.7) | 21 (28.0) | 0.805 |
| Neutropenia | 35 (34.7) | 22 (29.3) | 0.456 |
| Thrombocytopenia | 42 (41.6) | 27 (36.0) | 0.453 |
| Hand–foot syndrome | 0 (0.0) | 0 (0.0) | NA |
| Neuropathy | 1 (1.3) | 0 (0.0) | NA |
| Bleeding | 0 (0.0) | 0 (0.0) | NA |
NA – not available