Table 1. Echocardiographic analysis and tissue harvest in Sham and CAL mice.
| Shama | Sham + PFb | MIc | MI + PFd | ||
|---|---|---|---|---|---|
| BW | 48.79 ± 0.69 | 49.26 ± 1.61 | 46.13 ± 0.70 | 47.59 ± 0.78 | |
| TL | 10.77 ± 0.08 | 10.78 ± 0.12 | 10.41 ± 0.07 | 10.59 ± 0.11 | |
| HW | 0.21 ± 0.01 | 0.23 ± 0.01 | 0.25 ± 0.01* | 0.22 ± 0.01# | |
| LW | 0.23 ± 0.01 | 0.26 ± 0.02 | 0.37 ± 0.02* | 0.32 ± 0.01# | |
| HW/BW | 4.37 ± 0.16 | 4.72 ± 0.19 | 5.48 ± 0.31* | 4.66 ± 0.19# | |
| LW/BW | 4.71 ± 0.20 | 5.23 ± 0.28 | 8.04 ± 0.44* | 6.69 ± 0.21# | |
| BNP | 120.06 ± 9.86 | 117.62 ± 15.53 | 515.17 ± 50.75* | 399.03 ± 41.37# | |
| Day 30 | 68.48 ± 3.80 | 65.84 ± 2.34 | 18.89 ± 1.33* | 27.87 ± 1.31# | |
| LVEF | Day 60 | 70.48 ± 2.12 | 75.52 ± 2.08 | 15.26 ± 2.21* | 22.22 ± 2.10# |
| Day 90 | 68.93 ± 2.67 | 71.43 ± 4.66 | 12.42 ± 0.88* | 22.30 ± 1.62# | |
| Day 30 | 38.26 ± 3.12 | 36.08 ± 1.78 | 8.73 ± 0.64* | 13.21 ± 0.67# | |
| FS | Day 60 | 39.48 ± 1.58 | 43.90 ± 1.71 | 7.03 ± 1.06* | 10.39 ± 1.04# |
| Day 90 | 38.44 ± 2.06 | 41.05 ± 3.71 | 5.67 ± 0.41* | 10.58 ± 0.74# | |
| Day 30 | 22.23 ± 4.56 | 27.87 ± 2.57 | 146.01 ± 14.80* | 117.51 ± 6.79# | |
| LV Vol;s | Day 60 | 20.77 ± 3.78 | 17.07 ± 2.61 | 165.85 ± 13.13* | 133.56 ± 11.99# |
| Day 90 | 23.11 ± 2.82 | 21.83 ± 4.69 | 196.45 ± 13.05* | 123.72 ± 10.43# |
CAL: coronary artery ligation; MI: myocardial infarction; PF: treated with PF-573228; BW: body weight; TL: tail length; HW: heart weight; LW: lung weight; BNP: brain natriuretic peptide(pg/ml); LVEF: left ventricular ejection fraction; FS: fractional shortening; LV Vol; s: systolic left ventricular volume; a: n = 6; b: n = 6; c: n = 10 (1 month), n = 9(2 month), n = 8(3 month);d:n = 10 (1 month), n = 10 (2 month), n = 9 (3 month); Values are means ± SEM of three separate M-mode measurements. *p < 0.05 vs. Sham & Sham + PF #P < 0.05 vs. MI.