Figure 3. Dose-dependent effect of complex 1 on HRE activity as determined by a dual luciferase reporter assay.
Hypoxic MC3T3-E1 cells were treated with indicated concentrations of complex 1 for 16 h. IC50 value of complex 1 is ca. 1.22 μM. Error bars represent the standard deviations of results obtained from three independent experiments.