Table 4. Female-specific DEGs/DMGs of potential relevance to CVD. and their expression/methylation changes observed in present study or reported clinical studies (where available).

Gene	Direct evidence of links with CVD pathogenesis	Mechanistic basis of links with CVD	Current study		Vasclular inflam-mation28	Chronic artery occlussion48	Myocardial infarction63	Coronary heart disease64	Coronary artery disease65	Peripheral arterial disease66	Myocardial infarction67	Venous thrombo-embolism68	Atherosus-ceptibility69
			expr*	meth#	expr*	expr*	expr*	expr*	expr*	expr*	expr*	expr*	meth#
F2R (PAR1)	polymorphisms in human CVD14	thrombin signaling/vascular haemostasis	down					down			down
GP5				up
FYN	transgenic mice19			down								up
IGF1R				up									up
EGF				up
EPS8	transgenic mice24			up
RPTOR	transgenic mice26			up
HMOX1	polymorphisms and differential expression in human CVD28; transgenic mice28	anti-inflammatory	down		down
HDAC4		regulation of hypertrophy
BCL2L1		anti-apoptotic		down				up
CACNA1D	polymorphisms in human CVD37; transgenic mice35,36	calcium signalling		up
TANGLN	polymorphisms in human CVD70; transgenic mice42	VSMC/endothelial cell function	down
SYNE1	polymorphisms in human CVD37; transgenic mice35,36		down								down
IL32	differential expression in human CVD45; transgenic mice45	pro-inflammatory		down
PLIN5	transgenic mice46	oxidative stress		down
HNRNPUL1	polymorphisms in human CVD47	unknown		down
miR-30d	differential expression in human CVD48	regulation of cardiomyocyte apoptosis71		up		up	down
C14orf43	differential expression in human CVD61	unknown		down						down
C1orf21	differential expression in human CVD59	unknown	down					down
ST3GAL1	differential expression in human CVD59	unknown		down				up
ZNF19	differential expression in human CVD59	unknown		up				down

The genes are listed in the order in which they are discussed in the main text. Col. 1 presents evidence based on human population and transgenic animal studies.

^*Expression; ^#methylation.