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. 2017 Feb 22;7:42810. doi: 10.1038/srep42810

Figure 1. P-CTX-1 subtype selectivity assessed using a high-throughput membrane potential FLIPRTetra assay.

Figure 1

(a) P-CTX-1 concentration-dependently potentiated veratridine-induced responses in mammalian cells heterologously expressing NaV1.1–NaV1.8 with little subtype selectivity. (b) P-CTX-1 (10 nM) induced shifts in the voltage of activation at NaV1.1–NaV1.8 and the voltage-dependence of inactivation at NaV1.2, NaV1.3 and NaV1.4. Data are presented as mean ± SEM from n = 3–6 independent experiments.