Table 2. Effects of P-CTX-1 on Na_V channel activation and inactivation kinetics.

	P-CTX-1	Time to peak (ms)	Inactivation Time Constant (ms)
NaV1.1	—	1.23 ± 0.05	2.10 ± 0.26
	+	1.15 ± 0.10	1.20 ± 0.17*
NaV1.2	—	1.06 ± 0.05	1.45 ± 0.17
	+	0.78 ± 0.07*	0.79 ± 0.04*
NaV1.3	—	1.08 ± 0.09	0.89 ± 0.09
	+	1.05 ± 0.07	0.61 ± 0.05*
NaV1.4	—	0.69 ± 0.04	0.35 ± 0.04
	+	0.88 ± 0.11	0.46 ± 0.04
NaV1.5	—	0.86 ± 0.06	0.85 ± 0.11
	+	0.81 ± 0.07	1.00 ± 0.18
NaV1.6	—	1.03 ± 0.09	1.38 ± 0.22
	+	1.03 ± 0.08	1.09 ± 0.18
NaV1.7	—	1.09 ± 0.09	0.47 ± 0.04
	+	0.91 ± 0.06	0.49 ± 0.04
NaV1.8	—	1.06 ± 0.07	1.51 ± 0.21
	+	1.32 ± 0.10	3.06 ± 0.43*

Electrophysiological parameters at hNa_V1.1-hNa_V1.9 heterologously expressed in HEK293 cells were assessed using whole-cell voltage-clamp recordings. Data are reported as mean ± SEM from 4–10 cells. *Indicates P < 0.05 compared to control.