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. 2017 Feb 22;7:43108. doi: 10.1038/srep43108

Table 2. Summary of transcripts in S. mussotii encoding enzymes involved in the secoiridoid pathway.

Pathway Gene Gene name E.C. number KO SmTc
MVA ACCT1 acetyl-CoA C-acetyltransferase 2.3.1.9 K00626 SmTc_2083
ACCT2 acetyl-CoA C-acetyltransferase 2.3.1.9 K00626 SmTc_5029
ACCT3 acetyl-CoA C-acetyltransferase 2.3.1.9 K00626 SmTc_33675
HMGS1 hydroxymethylglutaryl-CoA synthase 2.3.3.10 K01641 SmTc_5929
HMGS2 hydroxymethylglutaryl-CoA synthase 2.3.3.10 K01641 SmTc_7106
HMGS3 hydroxymethylglutaryl-CoA synthase 2.3.3.10 K01641 SmTc_8664
HMGS4 hydroxymethylglutaryl-CoA synthase 2.3.3.10 K01641 SmTc_81097
HMGR1 hydroxymethylglutaryl-CoA reductase 1.1.1.34 K00021 SmTc_1585
HMGR2 hydroxymethylglutaryl-CoA reductase 1.1.1.34 K00021 SmTc_10138
HMGR3 hydroxymethylglutaryl-CoA reductase 1.1.1.34 K00021 SmTc_15910
HMGR4 hydroxymethylglutaryl-CoA reductase 1.1.1.34 K00021 SmTc_22303
MVK mevalonate kinase 2.7.1.36 K00869 SmTc_7721
PMK phosphomevalonate kinase 2.7.4.2 K00938 SmTc_5121
MVD1 diphosphomevalonate decarboxylase 4.1.1.33 K01597 SmTc_2684
MVD2 diphosphomevalonate decarboxylase 4.1.1.33 K01597 SmTc_2834
MEP DXS1 1-deoxy-D-xylulose-5-phosphate synthase 2.2.1.7 K01662 SmTc_5909
DXS2 1-deoxy-D-xylulose-5-phosphate synthase 2.2.1.7 K01662 SmTc_7421
DXS3 1-deoxy-D-xylulose-5-phosphate synthase 2.2.1.7 K01662 SmTc_10119
DXS4 1-deoxy-D-xylulose-5-phosphate synthase 2.2.1.7 K01662 SmTc_13486
DXR 1-deoxy-D-xylulose-5-phosphate reductoisomerase 1.1.1.267 K00099 SmTc_8142
ISPD 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 2.7.7.60 K00991 SmTc_23281
ISPE 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 2.7.1.148 K00919 SmTc_19780
ISPF 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 4.6.1.12 K01770 SmTc_11729
GCPE (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase 1.17.7.1 K03526 SmTc_845
ISPH 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase 1.17.7.4 K03527 SmTc_757
IDI1 isopentenyl-diphosphate delta-isomerase 5.3.3.2 K01823 SmTc_744
IDI2 isopentenyl-diphosphate delta-isomerase 5.3.3.2 K01823 SmTc_1157
GPPS1 geranyl diphosphate synthase 2.5.1.1 K14066 SmTc_17467
GPPS2 geranyl diphosphate synthase 2.5.1.1 K14066 SmTc_6570
Secoiridoid GES geranyl diphosphate diphosphatase 3.1.7.11 K20979 SmTc_70847
G10H geraniol 10-hydroxylase 1.14.13.152 K15099 SmTc_41455
8HGO 8-hydroxygeraniol oxidoreductase 1.1.1.324   SmTc_81115
IS iridoid synthase 1.3.1.99 K20144 SmTc_35128
IO iridoid oxidase     SmTc_29298
7-DLGT 7-deoxyloganetic acid glucosyl transferase 2.4.1.323   SmTc_15909
DL7H 7-deoxyloganic acid hydroxylase     SmTc_8300
LAMT loganic acid O-methyltransferase 2.1.1.50   SmTc_23275
SLS1 secologanin synthase 1.3.3.9 K13400 SmTc_4315
SLS2 secologanin synthase 1.3.3.9 K13400 SmTc_16024