Figure 2. Effects of PVN infusion of PD98059 on renal sympathetic nerve activity (RSNA) and plasma norepinephrine (NE) in salt-induced hypertensive rats.
High-salt diet (HS) rats exhibited a significant higher RSNA (% of max) and higher level of plasma NE compared with the normal-salt (NS) diet rats (P < 0.05, n = 7). When compared with HS + PVN aCSF rats, PD98059 attenuated RSNA (% of max) and plasma NE in HS rats (P < 0.05, n = 7). *P < 0.05 vs control (NS + PVN aCSF) or NS + PVN PD98059); †P < 0.05, HS + PVN PD98059 vs HS + PVN aCSF.