Table 3. C-terminal phase-variable genes in N. gonorrhoeae.
Gene | FA1090 locus* | Repeat at in FA1090* | NCCP11945 locus† | Repeat in NCCP11945† | Amino acids after the repeat in each frame of NCCP11945‡‡‡ | FA19§ | FA6140|| | 35/02 ¶ | MA11# | N. gonorrhoeae candidacy** | ||
---|---|---|---|---|---|---|---|---|---|---|---|---|
ispH | NGO0072 | (G)8 | NGK_0106 | (G)8 | 26 | 50 | 61 | (G)8 | (G)8 | (G)8 | (G)8 | (Yes) |
Menbrane protein | NGO0691 | (G)6 | NGK_1211 | (G)7 | 23 | 8 | 186^ | (G)7 | (G)6 | (G)7 | (G)7 | Yes |
m afB cassette | WX61_RS02820 | (C)7 | NGK_1624 | (C)9 | 46 | 2 | 37 | deletion†† | (C)10 | (C)8 | (C)10 | Yes |
Pilin cassette | WX61_RS02820 | CCGC | NGK_2161 | (C)8 | 20 | 8 | 91¶ | (C)5GCC | CCGCC | (C)5 | CCT(C)5 | Yes |
*From the N. gonorrhoeae strain FA1090 genome sequence (NC_002946.2).
†From the N. gonorrhoeae strain NCCP11945 genome sequence (CP00150.1).
‡In each column are the number of amino acids encoded 3′ of the repeat before the closest termination codon in each of the three reading frames.
§From the N. gonorrhoeae strain FA19 genome sequence (NZ_CP012026.1).
||From the N. gonorrhoeae strain FA6140 genome sequence (NZ_CP012027.1).
¶From the N. gonorrhoeae strain 35/02 genome sequence (NZ_CP012028.1).
#From the N. gonorrhoeae strain MS11 genome sequence (NC_022240.1).
**Gene phase variation candidacy in N. gonorrhoeae. Yes, there is evidence of repeat tract variation between strains supporting phase variation. (Yes), although there is no variation between strains investigated here, tracts of this length vary in other genes (Chen et al., 1998; Shafer et al., 2002; Adamczyk-Poplawska et al., 2011).
††There is a 400 bp deletion in this strain encompassing the region that would contain this repeat.