Table 4.

Multiple regression analyses

	β	t test	p
CVLT Trials 1–5
CA1 α-synuclein	−0.237	−2.40	0.019
CA1 plaques	−0.054	−0.49	0.620
CA1 tangles	−0.395	−3.35	0.001
Test–death interval	0.537	4.97	0.000
CVLT short delay
CA1 α-synuclein	−0.255	−2.47	0.016
CA1 plaques	0.047	0.42	0.679
CA1 tangles	−0.472	−3.84	0.000
Test–death interval	0.409	3.63	0.001
CVLT long delay
CA1 α-synuclein	−0.203	−1.96	0.053
CA1 plaques	0.067	0.59	0.559
CA1 tangles	−0.498	−4.03	0.000
Test–death interval	0.422	3.73	0.000
CVLT recognition
CA1 α-synuclein	−0.131	−1.16	0.251
CA1 plaques	−0.009	−0.07	0.941
CA1 tangles	−0.335	−2.47	0.016
Test–death interval	0.279	2.25	0.028
Visual reproduction: immediate
CA1 α-synuclein	−0.258	−2.36	0.021
CA1 plaques	0.159	1.32	0.193
CA1 tangles	−0.395	−2.93	0.005
Test–death interval	0.476	3.86	0.000
Visual reproduction: delay
CA1 α-synuclein	−0.304	−2.81	0.006
CA1 plaques	0.105	0.88	0.383
CA1 tangles	−0.481	−3.62	0.001
Test–death interval	0.380	3.13	0.003

The degree of α-synuclein pathology in CA1 of the hippocampus makes a significant independent contribution to the memory deficit of patients with DLB, above and beyond the significant contribution made by the burden of CA1 AD tangle pathology. The same pattern of results was observed for the CVLT Trial 1–5 learning measure when total hippocampal α-synuclein burden (rather than just CA1) was used in the first model. All models were highly significant (p values < 0.001). Standardized β values and significance levels for inclusion in the various models are shown for each variable.